<b id="zbvtg"></b>
    <u id="zbvtg"></u>

      <ruby id="zbvtg"><meter id="zbvtg"></meter></ruby>
      <acronym id="zbvtg"></acronym>

    1. <code id="zbvtg"></code>
        搜索: 您現在的位置: 北京愛富迪醫藥科技發展有限公司 >> 鉛中毒 >> 鉛中毒專欄 >> 鉛中毒學術前沿 >> 正文

        應用ALAD基因型篩查兒童鉛毒性易感人群之研究

        應用δ氨基-γ-酮戊酸脫氫酶基因型篩查兒童鉛毒性易感人群的研究

        Screening of high risk children for lead poisoning by analysing δ-aminolevulinate dehydratase (ALAD) genotype


        <<中華兒科雜志 >>2000年07期
        周建德 , 章依文 , 殷潔敏 , 顏崇淮 , 沈曉明 , 吳勝虎

        目的 通過對浙江者蘭溪市某污染區兒童δ氨基-γ-酮戊酸脫氫酶(ALAD)基因的遺傳多態性分析,探討遺傳因素對兒童血鉛水平的影響。 方法 整群抽取對鉛毒性較為敏感的6~10歲兒童229名。研究兩種ALAD等位基因(ALAD1和ALAD2)的頻率并測定血鉛水平,同時問卷調查每位研究對象血鉛水平的相關因素, 分析兩種ALAD等位基因對兒童血鉛水平的影響。 結果 (1)所研究兒童ALAD1-1型有211例,占92.1%;ALAD1-2型有18例,占7.9%;(2)攜有等位基因ALAD2的兒童血鉛水平幾何均數為117 μg/L,攜有等位基因ALAD1的兒童血鉛水平幾何均數為97 μg/L;(3)兒童血鉛水平相關因素分析發現,兒童ALAD基因型、性別、父親職業等9個因素與血鉛顯著相關。采用多元逐步回歸分析,發現ALAD基因型對血鉛水平的影響在排除協變量影響后仍有極顯著的統計學意義。 結論 本組兒童ALAD基因存在遺傳多態性;攜有含ALAD2等位基因的人群可能為鉛毒性作用的高危人群。
        Objective To explore the relationship between blood lead levels and the genetic polymorphism of the δ-aminolevulinate dehydratase (ALAD) gene. Methods The erythrocyte ALAD isozyme phenotypes and the blood lead levels were determined in a population of 229 pre-school children and primary school students aged 6-10 years. Both the school and their homes were within one community where a large smelter is located. An environmental questionnaire was filled for each subject. Results (1) The gene distribution of the ALAD isozyme phenotypes in these children was ALAD 1-1, 92.1%; ALAD 1-2, 7.9%; no ALAD 2-2 was detected. (2) The mean blood lead levels of the environmentally exposed children who were homozygous for the ALAD1 allele was 97 μg/L while the mean levels for those who were heterozygous for the ALAD2 was 117 μg/L or 20 μg/L higher. (3) Many factors were found to affect the blood lead levels, such as gender, ALAD isozyme phenotype, educational level of fathers and so on. After controlling these possible confounding variables by multiple regression, the contribution of the ALAD isozyme phenotype to the blood lead levels was still statistically significant. Conclusion These results indicate that individuals carrying the ALAD2 allele are more likely to have sustained increases in blood lead levels when exposed to a lead contaminated environment. The finding supports the hypothesis that individuals with the ALAD2 allele may be more susceptible to lead poisoning.

         

        Tags: 鉛中毒,排鉛,鉛損傷,兒童鉛中毒,鉛超標,如何排鉛  
        兒童排鉛 | 益童成長 | 力德希 | 排鉛口服液 | 排鉛的方法 | 如何排鉛 | 安全排鉛 | 鉛中毒原因 | 排鉛方案 | 鉛中毒預防 | 鉛中毒診斷
         
           
        版權所有:北京愛富迪醫藥科技發展有限公司©2008-2011 All Rights Reserved.  
        客服電話:010-58202358 58202359 65384908
        7×24小時商務熱線:18611841888 7×24小時客服熱線:18611264188
        聯系地址:北京市通州區黃廠鋪產業園29號 郵編:101101
        京ICP備14009604號-1 京公網安備110105003568號
        百度身份認證
        免费无遮挡又黄又爽网站无码国产_中文文字幕一级a片_久久精品午夜免费看_伊人高清无码网站

        <b id="zbvtg"></b>
          <u id="zbvtg"></u>

            <ruby id="zbvtg"><meter id="zbvtg"></meter></ruby>
            <acronym id="zbvtg"></acronym>

          1. <code id="zbvtg"></code>